| MeSH |
|
|
|
|
|
| Heart defects, congenital |
Warfarin |
Heparin |
| Anticoagulation |
Embolism |
|
Abstract
The insertion of a mechanical heart valve predisposes
to thrombosis and embolism, and for this reason, individuals with mechanical
valves who undergo dental/surgical procedures must take special precautions.
In this article, we illustrate a protocol for anticoagulation during such
procedures in individuals with mechanical valves.
Article
Individuals with mechanical heart valves are anticoagulated
in the long term with warfarin in order to reduce the risk of thromboembolism.1
It has been calculated that the rate of major thromboembolism without anticoagulation
is 8%, and that this risk is reduced by 75% with anticoagulation.2
The anticoagulated state is at risk of haemorrhage
during dental or surgical procedures, but reduction or discontinuation
of warfarin leads to increased risk of thrombo-embolic events. A similar
scenario also exists in patients who have suffered recent venous thromboembolism
and those with atrial fibrillation.
For this reason, intravenous heparin in used for
the prevention of thromboembolism in the perioperative period when the
International Normalisd Ratio (INR) is deliberately reduced, in order to
shorten the period at risk to the greatest possible extent.
In this table, we demonstrate the current protocol
used at the Hospital for Sick Children (London) and St. Luke’s Hospital
(Malta) for the management of children on long-term warfarin who need dental
or surgical procedures.
|
Day -2
|
Stop warfarin |
|
Day -1
|
Loading dose of heparin of 100u/kg bolus then infuse heparin at 25u/kg/hr |
|
Day 0
|
-
Check INR - can usually proceed with dental procedure/other surgery if
INR<2
-
Stop heparin 4 hours preoperatively
-
Restart heparin once tooth socket dry/active bleeding stops by giving another
loading dose of heparin and then continue maintenance, both as above
-
Give the usual maintenance dose of warfarin as soon as patient can drink
|
|
Day 1
|
Continue heparin infusion and warfarin usual maintenance dose |
|
Day 2
|
Check INR. If desired level reached, stop heparin, otherwise continue
both heparin infusion and maintenance dose of warfarin and recheck INR
day 3 etc |
References
-
Kearon C, Hirsh J. Management of anticoagulation before and after elective
surgery. N Engl J Med 1997;336:1506-1511
-
Cannegieter SC, Rosendaal FR, Briet E. Thromboembolic and bleeding complications
in patients with mechanical heart valve prostheses. Circulation 1994;89:635-641
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