News
Study finds that skipping breakfast does not ... Girls who skipped breakfast as part of a study into energy ... (16 Oct 2017)
Men develop irregular heartbeat earlier than ...   Men develop atrial fibrillation, about a decade earlier ... (16 Oct 2017)
Calcium in the prevention of postmenopausal ... A new clinical guide summarizes the evidence regarding the ... (15 Oct 2017)
Low Serum Calcium May Increase Risk of ... Findings of a new study published in Mayo Clinic Proceedings ... (10 Oct 2017)
Tai Chi holds promise as cardiac rehab ... The slow and gentle movements of Tai Chi hold promise as an ... (10 Oct 2017)

Dermfest 2017

Tuesday, 10 October 2017 17:15

Safe to treat dementia patients with clot-busting drugs Featured

Rate this item
(0 votes)

Stroke patients with dementia treated with intravenous thrombolysis using powerful clot-busting drugs are at no higher risk of brain haemorrhage or death than other patients receiving the same treatment, a study from Karolinska Institutet published in the journal Neurology reports.

Ischemic stroke is the most common form of stroke and is caused when a blood clot blocks the blood flow to the brain. Treatment with intravenous thrombolysis (IVT) using powerful clot-busting drugs within 4.5 hours of onset can greatly improve the prognosis and reduce the likelihood of patients losing the ability to speak or walk.

“Hospitals have tended to shy away from giving powerful clot-busting drugs to patients with dementia in the belief that such patients, especially those with Alzheimer’s disease, are more prone to brain haemorrhages,” says Sara Garcia-Ptacek, postdoc at Karolinska Institutet’s Department of Neurobiology, Care Sciences and Society. “We wanted to find out how great this risk really was.”

By studying data from the Swedish Dementia Registry (SveDem) from the years between 2010 and 2014 and cross-referencing them with the Swedish Stroke Registry, the researchers found 1,300 stroke patients with a previous diagnosis of some form of dementia. They then studied what percentage of the patients had received thrombolysis treatment for their stroke and how they had subsequently fared compared to a control group with stroke but without dementia. Doing so, they found that people under the age of 80 with dementia and stroke were not given intravenous thrombolysis as often as patients with stroke but no dementia.

“Yet we also saw that dementia patients over 80 suffering from a stroke received thrombolysis treatment as often as non-dementia patients with stroke, which was unexpected,” says Dr Garcia-Ptacek.

The researchers then examined the therapeutic outcomes for both groups that had received thrombolysis treatment to ascertain whether or not the risk of complications varied.

“It’s important to stress that sudden bleeding in the brain, what we call an intracerebral haemorrhage, a well-known complication that can arise in combination with thrombolysis treatment, was no more likely in people with dementia and stroke than in non-demented people with stroke when both groups received IVT ,” says Maria Eriksdotter, professor in geriatric medicine at the same department.

The researchers also studied the risk of death after treatment and found that there was no difference between patients with dementia and those without who received IVT. They did, however, find worse functional outcome in dementia patients with stroke three months afterwards. These patients were also more likely to be discharged to nursing homes compared to stroke patients without dementia.

“Our study indicates that thrombolysis treatment is just as safe for dementia patients as for other patients with the same physical status and that the risk of treatment complications is no higher,” says Professor Eriksdotter. “Thus, IVT treatment can be considered in stroke patients with dementia.”

The study was financed with grants from the Swedish Stroke Association, the Swedish Order of St John, the Swedish Society for Medical Research, the Swedish Research Council and the Swedish Association of Local Authorities and Regions.


Source: Karolinska Institutet


Full bibliographic information:
Thrombolysis in acute ischemic stroke in patients with dementia: a Swedish registry study”. Neurology, online 6 October 2017

Read 38 times

TheSynapse Videos

0
0
0
0
0
0

Latest news

Highlights

  • AVAILABLE CLINICS

    Rational Pharmacy, Valley Road, B'Kara requires consultants & family doctors for early morning & afternoon sessions.

    Please contact 99891732 or This email address is being protected from spambots. You need JavaScript enabled to view it. for more information.

    Written on October 09, 2017

Links

Join

Connect with other Medical Professionals on fb in a closed facebook group

Login

Template Settings

Theme Colors

Cyan Red Green Oranges Teal

Layout

Wide Boxed Framed Rounded
Patterns for Layour: Boxed, Framed, Rounded
Top
We use cookies to improve our website. By continuing to use this website, you are giving consent to cookies being used. More details…