This website is intended for Medical Professionals only. By using this site you confirm that you are a healthcare professional.

News
Keep it pumping Series - Episode 3       This is the third in a six-part series ... (20 Oct 2018)
Keep it pumping Series - Episode 2       This is the first in a six-part series ... (20 Oct 2018)
Keep it pumping Series - Episode 1 This is the first in a six-part series dealing with Heart ... (20 Oct 2018)
CHRONIC VENOUS DISEASE Log on to TheSynapse eLearning for a deeply insightful ... (20 Oct 2018)
Friday, 06 July 2018 16:19

Extended Tamoxifen Therapy May Increase Risk of Endometrial Cancer Featured

Rate this item
(0 votes)

There is clear evidence that extended adjuvant tamoxifen therapy for 10 years reduces local recurrence and improves breast cancer-free survival in women with oestrogen receptor–positive breast cancer.

An analysis of large randomized controlled trials, however, reveals that extended use is linked with a two-fold increased risk of developing endometrial (womb) cancer, when compared with standard 5 years of tamoxifen.

While more research is needed, the BJS(British Journal of Surgery) findings suggest that screening for endometrial cancer may be warranted in patients who receive extended tamoxifen therapy.

"There is a paucity of clear evidence on how we should best manage endometrial cancer risk in extended tamoxifen therapy. This is a research area that requires immediate focus with expansion of extended tamoxifen therapy regimes," said lead author Dr.Christina Fleming, of St. Vincent’s Hospital Group, in Dublin, Ireland.


Source: Wiley
Full bibliographic information

Meta-analysis of the cumulative risk of endometrial malignancy and systematic review of endometrial surveillance in extended tamoxifen therapy, British Journal of Surgery.

 

Read 286 times Last modified on Monday, 09 July 2018 10:35

TheSynapse e-Learning

0
0
0
0
0
0

Latest news

Highlights

  • Dermfest 2018

    Dermfest is fast approaching.

    Have you registered?

    If not click on the video to know more about this year's event. 

    Written on October 19, 2018 Read more...

Join

Connect with other Medical Professionals on fb in a closed facebook group

captcha  

Login

Template Settings

Theme Colors

Cyan Red Green Oranges Teal

Layout

Wide Boxed Framed Rounded
Patterns for Layour: Boxed, Framed, Rounded
Top
We use cookies to improve our website. By continuing to use this website, you are giving consent to cookies being used. More details…